ALDEA is developing novel enzyme activators to enhance the removal of toxic aldehydes, including those associated with the common flushing response to alcohol in persons of East Asian descent.
Private | Palo Alto, CA
Amicus is pioneering next-generation oral therapies for the management of human genetic diseases.
Public (FOLD) | Cranbury, NJ
BiPar is developing a potential new class of tumor-selective drugs designed to meet the unmet needs of cancer patients.
Acquired by Sanofi (EURONEXT: SAN) (NYSE: SNY)
Calixa is developing hospital-based antibiotics to treat infections resulting from resistant strains of bacteria.
Acquired by Cubist Pharmaceuticals
Cell Pathways is a development-stage pharmaceutical company focused on novel medications to treat and prevent cancer and certain autoimmune diseases.
Public. Acquired by OSI Pharmaceuticals (OSIP)
Centocor revolutionized the science of immunology and has been a leader in the field of cancer and immune-disorders for over 20 years.
Public (CNTO) | Malvern, PA
Cerexa is an innovative biopharmaceutical company focused on developing therapies for the treatment of serious and life–threatening infections.
Acquired by Forest Labs (FRX)
Chimerix is developing orally bioavailable antiviral therapies for unmet medical needs in immunocompromised patient populations, including transplant and oncology, HIV and HBV.
Public (CMRX) | Durham, NC
Civitas is focused on developing pulmonary delivery therapies uniquely able to deliver large and precise doses via a simple inhalational device to address significant unmet need medical needs. The company’s lead program is for patients with Parkinson’s disease.
Private | Chelsea, MA
CombinatoRx is pioneering the new field of synergistic combination pharmaceuticals to provide a renewable and previously untapped source of novel drug candidates.
Public (CRXX) | Boston, MA
CytomX is creating Probodies, which are masked antibodies that remain inert in healthy tissue but are activated in the disease microenvironment, improving the therapeutic index and utility of antibody drugs.
Private | South San Francisco, CA
Dermira is developing topical treatments for moderate to severe acne.
Private | Redwood City, CA
Durata is a biopharmaceutical company pursuing late-stage clinical development of novel antibiotic programs.
Public (DRTX) | Morristown, NJ
Elevation Pharmaceuticals is focused on the development of new aerosol therapies for the treatment of COPD (chronic obstructive pulmonary disease).
Acquired by Sunovion Pharmaceuticals
Eon Lab is a drug manufacturer that develops, manufactures, and markets a broad range of generic pharmaceutical products.
Public. Acquired by Novartis (NVS)
Esperion is a biopharmaceutical company focused on the discovery and development of therapies for the treatment of cardiovascular disease.
Public. Acquired by Pfizer (PFE)
Personalized medicine through population genomics and informatics.
Public. Acquired by Clinical Data (CLDA)
GenVec develops gene therapy products.
Public (GNVC) | Gaithersburg, MD
Kalidex is developing next-generation, broad-spectrum antibiotics for the treatment of serious infections.
Private | Menlo Park, CA
Labrys is developing a monoclonal antibody treatment for the prophylaxis of chronic migraine.
Private | San Francisco, CA
Liquidia Technologies Inc. is a nanotechnology company that designs and manufactures precisely engineered particles and films for a variety of life and material science applications.
Private | Research Triangle Park, NC
Marinus is creating a new class of neurologic drugs that may revolutionize the treatment of epilepsy in women and infants.
Private | Branford, CT
Matrix Pharmaceutical develops novel local and systemic cancer treatments that may improve or extend the lives of people living with cancer.
Public (MATX)
Novira is an antiviral drug discovery company focused on the development of its capsid-targeting antivirals for the treatment of chronic hepatitis B (HBV) and HIV infections.
Private | Radnor, PA
OraPharma is a specialty pharmaceutical company focused therapeutics for oral health.
Public. Acquired by Johnson & Johnson (JNJ)
Peninsula Pharmaceuticals is developing new antibiotic medications to treat life-threatening infections.
Acquired by Johnson & Johnson (JNJ)
Phylogix is an early-stage pharmaceutical company developing chemoprotectant compounds.
Private | Waltham, MA
Pozen is a pharmaceutical company developing therapeutic advancements for treatment of acute migraine.
Public (POZN)
Praecis Pharmaceuticals is a biopharmaceutical company focused on Peptide-based therapeutics that have the potential to address unmet medical needs or improve existing therapies.
Public. Acquired by GlaxoSmithKline (GSK)
Sopherion is a therapeutics platform company initially focused on cancer.
Private | Princeton, NJ
Theraclone Sciences harnesses the power of the human immune system to treat cancer and infectious diseases.
Private | Seattle, WA
Tobira develops novel drugs to help in the treatment of HIV and AIDS.
Private | Manalapan, NJ
VaxInnate invents vaccines that can be rapidly tailored to treat influenza and major pandemic illnesses.
Private | Cranbury, NJ
Brent Ahrens
Stephen Bloch
Peter Farina
Wende Hutton
Seth Rudnick
Tim Shannon